反应详情

A mixture of 0.0125 mole 3-cyano-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine, 1.1 g of hydroxylamine hydrochloride, 200 ml of 99% ethanol and 5.2 ml of a 20% potassium carbonate solution in water was refluxed for 22 hours. The reaction mixture was filtered and the filtrate was concentrated. The residue was treated with 100 ml of water and the crystalline solid was filtered off and was washed with water.

1. temperaturewas refluxed for 22 hours
2. filtrationThe reaction mixture was filtered
3. concentrationthe filtrate was concentrated
4. additionThe residue was treated with 100 ml of water
5. filtrationthe crystalline solid was filtered off
6. washwas washed with water