1-Methylpiperazine → 1-[2-(2-Imidazolylmethyl) phenylthiocarbamoyl]-4-methylpiperazine

HRID 2164818Notes

Reaction equation

HRID 2164818 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:10]=1[CH2:9][C:8]1[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=1[NH:6][C:5]2=[S:15].[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>C(Cl)Cl>[NH:4]1[CH:3]=[CH:2][N:1]=[C:10]1[CH2:9][C:8]1[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=1[NH:6][C:5]([N:20]1[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]1)=[S:15]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 1334490411H-imidazo[1,2-c][1,3]benzodiazepine-5(6H)-thione

Product 1

HCID 204033081-[2-(2-Imidazolylmethyl) phenylthiocarbamoyl]-4-methylpiperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The mixture of 2.1 g of 11H-imidazo[1,2-c][1,3]benzodiazepine-5(6H)-thione, 23 ml of methylene chloride and 1.0 g of 1-methylpiperazine is stirred at room temperature for 15 hours. The crystalline product formed is filtered off and washed with methylene chloride, to yield 1-[2-(2-imidazolylmethyl)phenylthiocarbamoyl]-4-methylpiperazine.

Workup

  1. customThe crystalline product formed
  2. filtrationis filtered off
  3. washwashed with methylene chloride

Sources & evidence

ORD record
ord-cd91e45a962e4c1e9a7da5487cff61b9
Source dataset
uspto-grants-1985_03
Patent number
US04507311

Reaction notes

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