Acetone → HCID 14329998, compound

HRID 2164962Notes

Reaction equation

HRID 2164962 reaction equation
[Cl:1][C:2]1[C:3]([OH:15])=[C:4]([CH2:12][CH2:13][CH3:14])[C:5]([OH:11])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.[CH2:16]([O:18][C:19](=[O:41])[CH2:20][O:21][C:22]1[CH2:23][C:24]([O:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]Br)(CCC)[C:25]([C:28](=[O:30])[CH3:29])=[CH:26][CH:27]=1)[CH3:17].C(=O)([O-])[O-].[K+].[K+].[CH3:48][C:49]([CH3:51])=O>CN(C)C=O>[CH2:16]([O:18][C:19](=[O:41])[CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28](=[O:30])[CH3:29])=[C:24]([O:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][O:15][C:3]2[C:2]([Cl:1])=[CH:7][C:6]([C:8](=[O:10])[CH3:9])=[C:5]([OH:11])[C:4]=2[CH2:12][CH2:13][CH3:14])[C:23]=1[CH2:48][CH2:49][CH3:51])[CH3:17]

Participants

6

Reactant 4

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 133891721-(5-Chloro-2,4-dihydroxy-3-propylphenyl)ethan-1-oneHCID 70420308HCID 70420308, compound

Product 1

HCID 14329998HCID 14329998, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 1.10 g (0.0049 mole) of 1-(5-chloro-2,4-dihydroxy-3-propylphenyl)ethanone, 2.08 g (0.0049 mole) of [4-acetyl-3-[(5-bromopentyl)oxy]-3-propylphenoxy]acetic acid ethyl ester and 1.33 g (0.0097 mole) of potassium carbonate in 40 ml of anhydrous acetone and 20 ml of anhydrous dimethylformamide was stirred at reflux for 22 hours. The reaction mixture was concentrated in vacuo and the residue was purified by HPLC using 25% ethyl acetate-hexane to give 0.96 g (34% yield) of [4-acetyl-3-[5-(4-acetyl-6-chloro-3-hydroxy-2-propylphenoxy)pentyloxy]-2-propylphenoxy]acetic acid ethyl ester as an oil.

Workup

  1. temperatureat reflux for 22 hours
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe residue was purified by HPLC

Sources & evidence

ORD record
ord-542db6c19ab74d54ba0283329ee8db11
Source dataset
uspto-grants-1985_03
Patent number
US04507498

Reaction notes

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