反应详情

温度

0 °C

7-Fluoro-6-o-tolylamino-1H-benzoimidazole-5-carboxylic acid methyl ester 7a (1.47 g, 4.92 mmol) is suspended in 1:1 THF:MeOH mixture (44 mL) and cooled to −78° C. under a nitrogen atmosphere. A solution of NIS (1.66 g, 7.39 mmol) in THF (2 mL) is added followed by a MeOH (2 mL) solution of TsOH.H2O (1.87 g, 9.84 mmol). After 30 minutes, the reaction mixture is warmed to 0° C. and 1 mL methylene chloride is added. The reaction is slowly allowed to warm to room temperature with stirring over 16 hours. The reaction mixture is quenched by the addition of 10% Na2S2O4 solution. The reaction mixture is then diluted with water and ethyl acetate and the layers separated. The aqueous layer is extracted with ethyl acetate. The combined organic extracts are dried (Na2SO4) and concentrated under reduced pressure. The recovered solid is triturated with MeOH to give 1.45 g (69%) pure desired product: MS ESI (+) m/z 426 (M+1) detected; MS ESI (−) m/z 424 (M−1) detected.

1. temperatureto warm to room temperature
2. customThe reaction mixture is quenched by the addition of 10% Na2S2O4 solution
3. additionThe reaction mixture is then diluted with water and ethyl acetate
4. customthe layers separated
5. extractionThe aqueous layer is extracted with ethyl acetate
6. dry with materialThe combined organic extracts are dried (Na2SO4)
7. concentrationconcentrated under reduced pressure
8. customThe recovered solid is triturated with MeOH