Trifluoroacetic acid → HCID 131716455, compound

HRID 2165278Notes

Reaction equation

HRID 2165278 reaction equation
C(OC([NH:8][C@H:9]1[C@H:12]([CH3:13])[N:11]([O:14][CH2:15][C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[C:10]1=[O:26])=O)(C)(C)C.[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30]>ClCCl>[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[NH2:8][C@H:9]1[C@H:12]([CH3:13])[N:11]([O:14][CH2:15][C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[C:10]1=[O:26]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 56634376HCID 56634376, compound

Product 1

HCID 131716455HCID 131716455, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
-10 °C

Procedure

(3S-trans) -[[3-[(t-Butyloxycarbonyl)amino]-4-methyl-2-oxo-1-azetidinyl]oxy]acetic acid. phenylmethyl ester (3.6g) was dissolved in 5 ml of dichloromethane and the solution was cooled to -10° C. Trifluoroacetic acid (25ml) was added dropwise and the mixture was stirred for 20 minutes at -10° C. After evaporation, the residue was treated with ether yielding 2.5 g of the title compound.

Workup

  1. customAfter evaporation
  2. additionthe residue was treated with ether yielding 2.5 g of the title compound

Sources & evidence

ORD record
ord-a40367852c084f3fb2d897c77b1b99c4
Source dataset
uspto-grants-1990_07
Patent number
US04939253

Reaction notes

Loading…