反应详情

A mixture of 5.1 g of 4-cyanophenol, 10 g of 3-(5-bromopentyl)-5-methylisoxazole, 8 g of potassium carbonate, 1 g of potassium iodide and 75 ml of acetonitrile was heated at reflux for 24 hours. The product was isolated and distilled, first at 115°-200° C.(0.1 mm) and then at 160°-190° C.(0.05 mm) to yield a yellow oil which crystallized upon cooling. Recrystallization from hexane-ether afforded 6.2 g of 3-[5-(4-cyanophenoxy)pentyl]-5-methylisoxazole, m.p. 61°-62° C.

1. temperaturewas heated
2. temperatureat reflux for 24 hours
3. customThe product was isolated
4. distillationdistilled, first at 115°-200° C.(0.1 mm)
5. customat 160°-190° C.(0.05 mm) to yield a yellow oil which
6. customcrystallized
7. temperatureupon cooling
8. customRecrystallization from hexane-ether