Acetaldehyde → HCID 56621722, compound

HRID 2166020Notes

Reaction equation

N1CCC[CH2:3][CH2:2]1.[Cl:7][CH2:8][C:9](=[O:18])[CH2:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12].C(=O)C>>[Cl:7][CH2:8][C:9](=[O:18])[C:10](=[CH:2][CH3:3])[C:11]([O:13][C:14]([CH3:15])([CH3:17])[CH3:16])=[O:12]

Participants

Reactant 3

HCID 177Acetaldehyde

HCID 8082Piperidine

HCID 2724514tert-Butyl 4-chloro-3-oxobutyrate

Product 1

HCID 56621722HCID 56621722, compound

Conditions

Temperature: -20 °C

Procedure

1.5 ml of piperidine are added dropwise to a stirred mixture of 212 g (1.1 mol) of tert.-butyl 4-chloro-3-oxobutyrate and 97 g (2.2 mol) of acetaldehyde at -20° C. under nitrogen. The mixture is subsequently stirred at -20° C. for six hours and is then worked up analogously to Example 2. Crude yield: 210 g, content according to gas chromatography: 6% of starting material, 52+37% of an isomer mixture of the product. The product is further processed in the crude form.

Sources & evidence

ORD record: ord-5646594816a3403f885d07b8f20a203f
Source dataset: uspto-grants-1990_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04943568

Reaction notes

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