4-Methoxy-o-phenylenediamine → HCID 15718785, compound

HRID 2166124Notes

Reaction equation

HRID 2166124 reaction equation
[N:1]([CH:4]1[CH2:9][CH2:8][N:7]([CH3:10])[CH2:6][CH2:5]1)=[C:2]=[S:3].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([NH2:20])[C:16]([NH2:19])=[CH:17][CH:18]=1>O1CCCC1>[NH2:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][C:15]=1[NH:20][C:2]([NH:1][CH:4]1[CH2:9][CH2:8][N:7]([CH3:10])[CH2:6][CH2:5]1)=[S:3]

Participants

4

Reactant 2

HCID 1534044-Methoxy-o-phenylenediamineHCID 157187604-isothiocyanato-1-methylpiperidine

Product 1

HCID 15718785HCID 15718785, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 37.5 parts of 4-isothiocyanato-1-methylpiperidine, 21.8 parts of 4-methoxy-1,2-benzenediamine and 270 parts of tetrahydrofuran was stirred and refluxed for 2 hours. The whole was evaporated, yielding 44 parts (100%) of N-(2-amino-5-methoxyphenyl)-N'-(1-methyl-4-piperidinyl)thiourea as a residue (interm. 26).

Workup

  1. temperaturerefluxed for 2 hours
  2. customThe whole was evaporated

Sources & evidence

ORD record
ord-302fdc34d92b47179aaf8810b77aad1d
Source dataset
uspto-grants-1990_07
Patent number
US04943580

Reaction notes

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