Hydrochloric Acid → N-[5-[3-(4-Methoxyphenyl)propoxy]pentyl]benzenemethanamine hydrochloride

HRID 2166160노트

반응식

HRID 2166160 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[ClH:27]>O>[ClH:27].[CH3:18][O:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][CH2:9][CH2:8][O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:26][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:12][CH:13]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 7504BenzylamineHCID 197980251-[3-[(5-Bromopentyl)oxy]propyl]-4-methoxybenzene

생성물 1

HCID 20062857N-[5-[3-(4-Methoxyphenyl)propoxy]pentyl]benzenemethanamine hydrochloride

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1-[3-[(5-Bromopentyl)oxy]propyl]-4-methoxybenzene (2.0 g) was added to benzylamine (6 ml) at 120° under nitrogen. The solution was stirred for 2 h at 120° then added (hot) to 2N hydrochloric acid (50 ml) and water (25 ml). The resulting precipitate was collected by filtration, washed with 2N hydrochloric acid, water and ER then dried at 50° under vacuum to give the title compound as a white solid (1.79 g) m.p. 118°-121°. The following compound was prepared in a similar manner:

후처리

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with 2N hydrochloric acid, water and ER
  3. customthen dried at 50° under vacuum

출처 및 근거

ORD 기록
ord-2c9325fea5a64b7eaecc18b92831e77b
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04943591

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