反应详情

温度

65 °C

Lithium hydroxide monohydrate (1.5 g, 36 mmol) was added to a solution mixture of 2-aminocarbonylamino-6-methoxycarbonylindole-3-carboxamide (Compound 2-17, 1.0 g, 3.6 mmol) in tetrahydrofuran, methanol and water (tetrahydrofuran/methanol/water=3/1/1, 50 mL), and the mixture was stirred at 65° C. for 7 hours. After the reaction mixture was concentrated under reduced pressure, 6 N hydrochloric acid (4 mL) was added to the residue under ice-cooling. The precipitated solid was washed with water (20 mL), chloroform (20 mL), and dried under reduced pressure to give the title compound (0.94 g) as a colorless solid (yield 99%).

1. concentrationAfter the reaction mixture was concentrated under reduced pressure, 6 N hydrochloric acid (4 mL)
2. additionwas added to the residue under ice-
3. temperaturecooling
4. washThe precipitated solid was washed with water (20 mL), chloroform (20 mL)
5. customdried under reduced pressure