反应详情

A mixture of 1.54 g of 1-cyclopropylmethyl-4-phenyl-6-methoxy-3,4-dihydro-2(1H)-quinazolinone, 0.48 g of sulfur and 10 ml of o-dichlorobenzene was stirred under reflux for 5 hours. The solvent was then removed under reduced pressure, and the residue was treated with hot acetone. The insoluble sulfur was filtered off and the filtrate was concentrated to dryness. The residue was recrystallized from toluene to give 1.35 g of 1-cyclopropylmethyl-4-phenyl-6-methoxy-2(1H)-quinazolinone, m.p. 114°-115° C.

1. temperatureunder reflux for 5 hours
2. customThe solvent was then removed under reduced pressure
3. additionthe residue was treated with hot acetone
4. filtrationThe insoluble sulfur was filtered off
5. concentrationthe filtrate was concentrated to dryness
6. customThe residue was recrystallized from toluene