Water → HCID 178510522, compound

HRID 2166559Notes

Reaction equation

HRID 2166559 reaction equation
N[C:2]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:10]2[C:5](=[N:6][C:7](N)=[C:8]([C:11]#[N:12])[CH:9]=2)[O:4][NH:3]1.[N:20]([O-])=O.[Na+].[OH2:24]>Cl>[NH2:20][C:9]1[C:8]([C:11]#[N:12])=[C:7]([OH:24])[N:6]=[C:5]2[O:4][N:3]=[C:2]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:10]=12

Participants

5

Reactant 3

HCID 962Water2×HCID 23668193Sodium NitriteHCID 86738576HCID 86738576, compound

Product 1

HCID 178510522HCID 178510522, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

0.4 g (1.59 mmole) of 3,6-diamino-5-cyano-3-phenyl-isoxazolo [5,4-b] pyridine (4a) is dissolved in 25 ml of 6N HCl in heat. Then 5 ml of H2O is added and mixed drop by drop with a solution of 0.4 g of NaNO2 in 5 ml of H2O. The solution is heated to boiling for 60 minutes. The precipitate is sucked off (removed) hot. The yield is 0.2 g (50 percent) of colorless plates, from glacial acetic acid, having a melting point of 251° C.

Workup

  1. temperaturein heat
  2. temperatureThe solution is heated
  3. custom(removed) hot

Sources & evidence

ORD record
ord-55926f923109405895d5423a29b4f5e4
Source dataset
uspto-grants-1983_06
Patent number
US04387231

Reaction notes

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