Phenethylamine → HCID 13150828, compound

HRID 2166591Notes

Reaction equation

HRID 2166591 reaction equation
[O:1]1[CH:6]([C:7]([OH:9])=[O:8])[CH:2]1[C:3]([OH:5])=O.[CH2:10]([K])[CH3:11].C(Cl)(=O)C(Cl)=O.[CH2:19]([NH2:27])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:19]([NH:27][C:3](=[O:5])[CH:2]1[O:1][CH:6]1[C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 1001PhenethylamineHCID 65578Oxalyl chlorideHCID 178461626HCID 178461626, compound

Product 1

HCID 13150828HCID 13150828, compoundYield 54.8%

Procedure

Following the procedure of Example 1, monoethyl potassium epoxysuccinate (1.0 g) was successively treated with oxalyl chloride (0.75 g) and phenethylamine (1.3 g) to give 0.72 g of ethyl N-phenethyl-2,3-epoxysuccinamate (Compound No. 15) as colorless needles melting at 80°-82° C.

Sources & evidence

ORD record
ord-10bc71989ccf404bb6f4e71437496ec9
Source dataset
uspto-grants-1983_06
Patent number
US04387238

Reaction notes

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