N-Methylbenzylamine → HCID 20499849, compound

HRID 2166605Notes

Reaction equation

[O:1]1[CH:6]([C:7]([OH:9])=[O:8])[CH:2]1[C:3]([OH:5])=O.[CH2:10]([K])[CH3:11].C(Cl)(=O)C(Cl)=O.[CH3:19][NH:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH3:19][N:20]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:3](=[O:5])[CH:2]1[O:1][CH:6]1[C:7]([O:9][CH2:10][CH3:11])=[O:8]

Participants

Reactant 3

HCID 7669N-Methylbenzylamine

HCID 65578Oxalyl chloride

HCID 178461626HCID 178461626, compound

Product 1

HCID 20499849HCID 20499849, compoundYield 46.4%

Procedure

Following the procedure of Example 34, monoethyl potassium epoxysuccinate (1.0 g) was successively treated with oxalyl chloride (0.75 g) and N-methylbenzylamine (1.3 g) to give 0.61 g ethyl N-methyl-N-benzyl-2,3-epoxysuccinamate (Compound No. 58) as colorless oil.

Sources & evidence

ORD record: ord-14da5f49103a4707b0712b95c3ab3001
Source dataset: uspto-grants-1983_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04387238

Reaction notes

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