反应详情

A mixture of ethyl 3-(2-furanyl)propionate (33.77 g) and ethyl formate (22.22 g) was added dropwise with stirring to a pre-cooled (0° C.) suspension of sodium hydride (50% in oil; 8.45 g) in dimethoxyethane (70 ml) maintaining the temperature below 0° C. throughout the addition. The reaction mixture was allowed to warm to room temperature then poured on to ice and water and extracted with ethyl acetate. The aqueous layer was acidified to pH 4 and re-extracted with ethyl acetate. These second ethyl acetate extracts were combined dried (MgSO4) and evaporated at reduced pressure to yield ethyl 3-(2-furanyl)-2-formylpropionate (19.0 g).

1. additionwas added dropwise
2. temperaturea pre-cooled
3. temperaturemaintaining the temperature below 0° C.
4. additionthroughout the addition
5. extractionextracted with ethyl acetate
6. extractionre-extracted with ethyl acetate
7. dry with materialThese second ethyl acetate extracts were combined dried (MgSO4)
8. customevaporated at reduced pressure