Hydrochloric Acid → HCID 178442519, compound

HRID 2166812Notes

Reaction equation

HRID 2166812 reaction equation
C[O-].[Na+].[Na].C(O[CH:8]=[C:9]([C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[CH:14][CH:13]=1)[CH:10]=O)C.Cl.[C:26]([C@H:29]1[CH2:34][CH2:33][C@H:32]([C:35]([NH2:37])=[NH:36])[CH2:31][CH2:30]1)(=[O:28])[NH2:27].Cl>CO>[CH2:18]([C:15]1[CH:14]=[CH:13][C:12]([C:9]2[CH:8]=[N:36][C:35]([C@H:32]3[CH2:31][CH2:30][C@H:29]([C:26]([NH2:27])=[O:28])[CH2:34][CH2:33]3)=[N:37][CH:10]=2)=[CH:17][CH:16]=1)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 5360545SodiumHCID 10942334Sodium MethoxideHCID 54033431HCID 54033431, compoundHCID 178479353HCID 178479353, compound

Product 1

HCID 178442519HCID 178442519, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a sodium methylate solution prepared by the addition of 3.2 g. of sodium to 125 ml. of methanol are added 12.6 g. of 3-ethoxy-2-(p-n-heptylphenyl)acrolein and then 9.9 g. of trans-4-carbamoylcyclohexane-carboxamidine hydrochloride. The mixture is stirred at 50° C. overnight. The mixture is then acidified with dilute hydrochloric acid and the suspension is filtered. The residue is washed neutral and dried in vacuo. For purification, the residue is boiled with ether. There is obtained trans-4-[5-(p-n-heptylphenyl)-2-pyrimidinyl]cyclohexane carboxamide which is difficultly soluble.

Workup

  1. filtrationthe suspension is filtered
  2. washThe residue is washed neutral
  3. customdried in vacuo
  4. customFor purification

Sources & evidence

ORD record
ord-d4dfd7f46b2349218a947594464201b8
Source dataset
uspto-grants-1983_06
Patent number
US04389329

Reaction notes

Loading…