反应详情

温度

0 °C

A 2M n-BuLi solution (5.8 mL, 11.6 mmol) was added to a −78° C. THF solution (60 mL) of 1,3-dichloro-5-(trifluoromethyl)benzene (2.5 g, 11.6 mmol). After 45 min neat DMF (0.39 mL, 5.0 mmol) was added, and the resulting solution was allowed to warm to 0° C. gradually, quenched with NH4Cl solution, and extracted with diethyl ether. The combined extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

1. customquenched with NH4Cl solution
2. extractionextracted with diethyl ether
3. dry with materialThe combined extracts were dried (Na2SO4)
4. concentrationconcentrated
5. custompurified via column chromatography