反应详情

温度

80 °C

9.90 g (69.6 mmol) ethylglycinate hydrochloride are suspended under argon in 100 mL of dry DMA. 24.3 mL (139 mmol) diisopropylethylamine and 10.21 g (46.4 mmol) of 2-bromo-6-fluoronitrobenzene are then added at RT. The orange solution is then heated to 80° C. for 16 h. After cooling, the reaction mixture is poured onto iced-cold water and the suspension is collected by filtration to afford, after drying in HV at 50° C., the title compound as a dark orange solid, which is used in the next step without further purification.

1. temperatureAfter cooling
2. filtrationthe suspension is collected by filtration
3. customto afford
4. customafter drying in HV at 50° C.
5. customthe title compound as a dark orange solid, which is used in the next step without further purification