反应详情

To a solution of 0.245 mmol of 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid in 2 ml dry THF were added at room temperature 0.736 mmol borane dimethyl sulphide complex and the mixture was stirred over night. The mixture was diluted with EtOAc and washed with saturated Na2CO3 solution and brine. The aqueous layer was extracted with EtOAc. The combined organic layers were washed, dried over MgSO4 and filtered. Evaporation of the solvent gave 60 mg of a pale yellow oil (93%).

1. washwashed with saturated Na2CO3 solution and brine
2. extractionThe aqueous layer was extracted with EtOAc
3. washThe combined organic layers were washed
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customEvaporation of the solvent