Water → HCID 90427644, compound

HRID 2167676Notes

Reaction equation

HRID 2167676 reaction equation
Br[C:2]1[C:10]2[C:6](=[CH:7][N:8]([CH3:11])[N:9]=2)[C:5]([CH3:12])=[CH:4][CH:3]=1.[C:13]([Cu])#[N:14].O>CN1C(=O)CCC1>[CH3:11][N:8]1[CH:7]=[C:6]2[C:10]([C:2]([C:13]#[N:14])=[CH:3][CH:4]=[C:5]2[CH3:12])=[N:9]1

Participants

5

Reactant 3

HCID 962WaterHCID 90426844HCID 90426844, compoundHCID 178418546HCID 178418546, compound

Product 1

HCID 90427644HCID 90427644, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

To a solution of 7-bromo-2,4-dimethyl-2H-indazole (1 eq.) in NMP, was added CuCN (2 equiv.) and heated at 130 oC for 16 h. On completion, water was added to quench the reaction, solid precipitated was filtered and purified by column chromatography to afford the title compound (40-60% yield)

Workup

  1. temperatureheated at 130 oC for 16 h
  2. customto quench
  3. customthe reaction, solid
  4. customprecipitated
  5. filtrationwas filtered
  6. custompurified by column chromatography

Sources & evidence

ORD record
ord-e3d5a352d9ef4c83b325391c075b8744
Source dataset
uspto-grants-2015_06
Patent number
US09045477B2

Reaction notes

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