5,5-Dibromobarbituric acid → HCID 86720747, compound

HRID 2167695Notes

Reaction equation

HRID 2167695 reaction equation
[C:1]([C:4]1[C:5](=[O:14])[NH:6][C:7]([C:10]([CH3:13])([CH3:12])[CH3:11])=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[Br:15]C1(Br)C(=O)NC(=O)NC1=O>O1CCCC1>[Br:15][CH2:2][C:1]([C:4]1[C:5](=[O:14])[NH:6][C:7]([C:10]([CH3:13])([CH3:12])[CH3:11])=[CH:8][CH:9]=1)=[O:3]

Participants

4

Reactant 2

HCID 948775,5-Dibromobarbituric acidHCID 18525961HCID 18525961, compound

Product 1

HCID 86720747HCID 86720747, compoundYield 71.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a tetrahydrofuran (5.0 mL) solution of 3-(acetyl)-6-tert-butylpyridin-2(1H)-one (0.50 g), 5,5-dibromobarbituric acid (0.41 g) was added, and the resultant was heated to reflux for 2 hours. A deposit formed during the course of concentration of the reaction solution under reduced pressure was filtered to obtain the title compound (0.28 g) as a light brown solid.

Workup

  1. temperaturethe resultant was heated
  2. temperatureto reflux for 2 hours
  3. customA deposit formed during the course of concentration of the reaction solution under reduced pressure
  4. filtrationwas filtered

Sources & evidence

ORD record
ord-1cc9fc32d2e34f9583424afce5384b1b
Source dataset
uspto-grants-2015_06
Patent number
US09045466B2

Reaction notes

Loading…