Triethylamine → HCID 178514733, compound

HRID 2167952Notes

Reaction equation

HRID 2167952 reaction equation
Cl.Cl.[O:3]1[CH2:8][CH2:7][N:6]([C@H:9]2[CH2:14][CH2:13][C@H:12]([NH2:15])[CH2:11][CH2:10]2)[CH2:5][CH2:4]1.F[C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH2:26])(=[O:25])=[O:24])=[CH:19][C:18]=1[N+:27]([O-:29])=[O:28].C(N(CC)CC)C>O1CCCC1>[O:3]1[CH2:4][CH2:5][N:6]([C@H:9]2[CH2:10][CH2:11][C@H:12]([NH:15][C:17]3[CH:22]=[CH:21][C:20]([S:23]([NH2:26])(=[O:25])=[O:24])=[CH:19][C:18]=3[N+:27]([O-:29])=[O:28])[CH2:13][CH2:14]2)[CH2:7][CH2:8]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 167824874-Fluoro-3-nitrobenzenesulfonamideHCID 178478723HCID 178478723, compound

Product 1

HCID 178514733HCID 178514733, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of trans-4-morpholinocyclohexanamine dihydrochloride (5 g, 19.44 mmol), 4-fluoro-3-nitrobenzenesulfonamide (4.32 g, 19.63 mmol) and triethylamine (20 ml, 143 mmol) in tetrahydrofuran (60 ml) was stirred for 16 hours at room temperature. The solid product was filtered off, washed with tetrahydrofuran, ether, dichloromethane (3×) and dried under vacuum.

Workup

  1. filtrationThe solid product was filtered off
  2. washwashed with tetrahydrofuran, ether, dichloromethane (3×)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-91f9e0963d9d408382f59553acd75eff
Source dataset
uspto-grants-2015_06
Patent number
US09045475B2

Reaction notes

Loading…