Hydrochloric Acid → HCID 86710204, compound

HRID 2168200Notes

Reaction equation

HRID 2168200 reaction equation
[ClH:1].[CH3:2][N:3]([CH:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:18]3[C:25]([CH3:26])=[CH:24][NH:23][C:19]=3[N:20]=[CH:21][N:22]=2)[CH2:13][CH2:12]1)C(=O)OC(C)(C)C>O1CCOCC1>[ClH:1].[CH3:2][NH:3][CH:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:18]3[C:25]([CH3:26])=[CH:24][NH:23][C:19]=3[N:20]=[CH:21][N:22]=2)[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86710203HCID 86710203, compound

Product 1

HCID 86710204HCID 86710204, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4M HCl in 1,4-Dioxane (6 mL) was added to 1,1-dimethylethyl methyl[1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]carbamate D22 (0.793 g) and the mixture stirred for 2 hours. The mixture was filtered under vacuum. The solid was washed with dioxane and Et2O. The white powder was dried under vacuum all the night to give the desired product D23 in 0.6479 g. LCMS [M+H][email protected] min (5 min run)

Workup

  1. filtrationThe mixture was filtered under vacuum
  2. washThe solid was washed with dioxane and Et2O
  3. customThe white powder was dried under vacuum all the night

Sources & evidence

ORD record
ord-69639569f53d4001b596bce4d8df25b1
Source dataset
uspto-grants-2015_06
Patent number
US09045485B2

Reaction notes

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