1,2-Dichloroethane → HCID 57382936, compound

HRID 2168247Notes

Reaction equation

HRID 2168247 reaction equation
[CH3:1][N:2]1[C:6]([C:7]([OH:9])=O)=[CH:5][N:4]=[CH:3]1.C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1.C(N(CC)C(C)C)(C)C.Cl.[CH3:34][C:35]1[C:43]2[C:42]([N:44]3[CH2:49][CH2:48][CH:47]([NH2:50])[CH2:46][CH2:45]3)=[N:41][CH:40]=[N:39][C:38]=2[NH:37][CH:36]=1>ClCCl>[CH3:1][N:2]1[C:6]([C:7]([NH:50][CH:47]2[CH2:46][CH2:45][N:44]([C:42]3[C:43]4[C:35]([CH3:34])=[CH:36][NH:37][C:38]=4[N:39]=[CH:40][N:41]=3)[CH2:49][CH2:48]2)=[O:9])=[CH:5][N:4]=[CH:3]1

Participants

7

Reactant 5

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 27735071-methyl-1H-imidazole-5-carboxylic acidHCID 86710200HCID 86710200, compound

Product 1

HCID 57382936HCID 57382936, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 1-methyl-1H-imidazole-5-carboxylic acid (61.2 mg, 0.486 mmol, commercially available from e.g. Maybridge, Apollo or Butt Park), EDC (107 mg, 0.560 mmol), HOBt (86 mg, 0.560 mmol) and N,N-diisopropylethylamine (0.163 nit, 0.934 mmol) in Dichloromethane (DCM) (2 mL), prestirred for 10 minutes, was added 1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine hydrochloride

Sources & evidence

ORD record
ord-9292f89098bf4b13af155ffc1939de34
Source dataset
uspto-grants-2015_06
Patent number
US09045485B2

Reaction notes

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