Trifluoroacetic acid → HCID 178511244, compound

HRID 2168430Notes

Reaction equation

HRID 2168430 reaction equation
C(OC(=O)[NH:7][CH2:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]#[N:16])[CH2:11][CH2:10]1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:16][CH2:15][C@H:12]1[CH2:13][CH2:14][C@H:9]([C:8]#[N:7])[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453599HCID 178453599, compound

Product 1

HCID 178511244HCID 178511244, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl(trans-4-cyanocyclohexyl)methylcarbamate (500 mg) in dichloromethane (10 mL) was slowly added trifluoroacetic acid (2 mL) at 0° C. The reaction mixture was warmed to room temperature, stirred for 1 hour and concentrated to provide the title compound.

Workup

  1. customat 0° C
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-6cf4e1ac54774cbfa9978d25dc48346e
Source dataset
uspto-grants-2015_06
Patent number
US09045420B2

Reaction notes

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