Cyclobutylamine → [2-(tert-Butyl-dimethylsilanyloxy)-ethyl]-cyclobutyl-amine

HRID 2169325Notes

Reaction equation

HRID 2169325 reaction equation
[Si:1]([O:8][CH2:9][CH2:10][NH:11][CH:12]1[CH2:16][CH2:15][CH2:14]C1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].C1(N)CCC1.[Si](OCC=O)(C(C)(C)C)(C)C>>[Si:1]([O:8][CH2:9][CH2:10][NH:11][CH:12]1[CH2:16][CH2:15][CH2:14]1)([C:4]([CH3:5])([CH3:6])[CH3:7])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 75645CyclobutylamineHCID 41877882-((Tert-butyldimethylsilyl)oxy)acetaldehydeHCID 86725959[2-(Tert-butyl-dimethylsilanyloxy)-ethyl]-cyclopentylamine

Product 1

HCID 86725964[2-(tert-Butyl-dimethylsilanyloxy)-ethyl]-cyclobutyl-amine

Procedure

This compound was prepared following the same method as described for [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-cyclopentyl-amine (8e) from cyclobutylamine (1 g, 14.27 mmol) and 2-(tert-butyl-dimethylsilanyloxy)acetaldehyd (2.6 mg, 14.26 mmol). The product was obtained as a yellow gummy mass (400 mg, 12.22%).

Workup

  1. customThis compound was prepared
  2. customThe product was obtained as a yellow gummy mass (400 mg, 12.22%)

Sources & evidence

ORD record
ord-9bdb78472335491a9510331ca138312d
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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