Triethylamine → HCID 86670138, compound

HRID 2169595Notes

Reaction equation

HRID 2169595 reaction equation
[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH2:12][C:13]([OH:15])=O)[CH2:7][C@@H:6]3[CH2:16][O:17][CH2:18][CH2:19][N:5]3[C:4]=2[N:3]=1.CN(C(ON1N=[N:35][C:30]2[CH:31]=[CH:32]C=N[C:29]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.NC1C[O:48][CH2:47]C1.C(N(CC)CC)C>CN(C=O)C>[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH2:12][C:13]([NH:35][CH:30]3[CH2:29][CH2:47][O:48][CH2:32][CH2:31]3)=[O:15])[CH2:7][C@@H:6]3[CH2:16][O:17][CH2:18][CH2:19][N:5]3[C:4]=2[N:3]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 3365553Oxolan-3-amineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 86670136HCID 86670136, compound

Product 1

HCID 86670138HCID 86670138, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared in a manner similar to PREPARATION x26 using (R)-2-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)acetic acid (PREPARATION x25, 50 mg, 0.176 mmol), HATU (87 mg, 0.228 mmol), 4-aminotetrahydrofuran (27 mg, 0.263 mmol) and triethylamine (0.073 mL, 0.527 mmol) in DMF (2 mL). ESI-MS m/z [M+H]+ calc'd for C16H22ClN5O3, 368.15; found 368.3.

Sources & evidence

ORD record
ord-03404422a5fe4f399ee9c2277e98db2a
Source dataset
uspto-grants-2015_06
Patent number
US09045496B2

Reaction notes

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