N-methyl-2-pyrrolidone → NMP Methanol

HRID 2169656Notes

Reaction equation

HRID 2169656 reaction equation
[CH3:1][N:2]1[C:6](=[O:7])[CH2:5][CH2:4][CH2:3]1.CN1[C:14](=[O:15])N(C)CCC1.C1C2NC=C(O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)C=2C(Cl)=C(Br)C=1>CO>[CH3:1][N:2]1[C:6](=[O:7])[CH2:5][CH2:4][CH2:3]1.[CH3:14][OH:15]

Participants

5

Reactant 3

HCID 13387N-methyl-2-pyrrolidone2×HCID 65181X-GalHCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-2×

Product 1

HCID 22395687NMP Methanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Add 7 ml of either NMP or DMPU to 1 gram of X-gal and stir until dissolved. Bring to 10 ml with NMP or DMPU (whichever is already used). Add 90 ml of methanol and mix thoroughly.

Workup

  1. dissolutionuntil dissolved
  2. additionmix thoroughly

Sources & evidence

ORD record
ord-6fe9ce74632447eeb9f020f6ccd74bed
Source dataset
uspto-grants-2015_06
Patent number
US09046495B2

Reaction notes

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