Hydrochloric Acid → HCID 90386774, compound

HRID 2170205Notes

Reaction equation

HRID 2170205 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=2[F:32])=[C:6]([C:8]2[NH:9][C:10]([CH3:23])=[C:11]3[C:16]=2[CH:15]=[C:14]([C:17]([O:19]CC)=[O:18])[NH:13][C:12]3=[O:22])[CH:7]=1.[OH-].[Li+].Cl>O1CCCC1.CO.O.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=2[F:32])=[C:6]([C:8]2[NH:9][C:10]([CH3:23])=[C:11]3[C:16]=2[CH:15]=[C:14]([C:17]([OH:19])=[O:18])[NH:13][C:12]3=[O:22])[CH:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 86270710HCID 86270710, compound

Product 1

HCID 90386774HCID 90386774, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

A mixture of Example 24b (0.14 g, 0.305 mmol) and lithium hydroxide (0.073 g, 3.05 mmol) in tetrahydrofuran/methanol/water (2 mL each) was stirred at 80° C. for 2 hours. The mixture was cooled, diluted with water and brought to pH 4 with 1M HCl producing a yellow solid that was collected by filtration, washed with water and dried to constant mass (0.10 g, 76%).

Workup

  1. temperatureThe mixture was cooled
  2. filtrationthat was collected by filtration
  3. washwashed with water
  4. customdried to constant mass (0.10 g, 76%)

Sources & evidence

ORD record
ord-7c1a3e10464f4b61a8d585b53627617a
Source dataset
uspto-grants-2015_06
Patent number
US09050346B2

Reaction notes

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