Propylamine → HCID 90386794, compound

HRID 2170211Notes

Reaction equation

HRID 2170211 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:32][C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][C:34]=2[F:40])=[C:6]([C:8]2[N:9]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[C:10]([CH3:23])=[C:11]3[C:16]=2[CH:15]=[C:14]([C:17](OCC)=[O:18])[NH:13][C:12]3=[O:22])[CH:7]=1.[CH2:41]([NH2:44])[CH2:42][CH3:43]>CO>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:32][C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][C:34]=2[F:40])=[C:6]([C:8]2[N:9]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:29])[CH3:30])[C:10]([CH3:23])=[C:11]3[C:16]=2[CH:15]=[C:14]([C:17]([NH:44][CH2:41][CH2:42][CH3:43])=[O:18])[NH:13][C:12]3=[O:22])[CH:7]=1

Participants

4

Reactant 2

HCID 7852PropylamineHCID 90386782HCID 90386782, compound

Product 1

HCID 90386794HCID 90386794, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of Example 4e (0.05 g, 0.088 mmol) and propan-1-amine (1 mL, 12.16 mmol) in methanol (0.5 mL) in a sealed tube was heated by microwave at 120° C. for 2 hours, cooled and concentrated to afford the title compound (0.05 g, 98%). The product was used without purification.

Workup

  1. temperaturecooled
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-b3a34460d6554e7f804a64cfd2db9d5b
Source dataset
uspto-grants-2015_06
Patent number
US09050346B2

Reaction notes

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