HCID 90281393, compound → HCID 90281431, compound

HRID 2170370Notes

Reaction equation

HRID 2170370 reaction equation
[Br:1][C:2]1[C:3]([C@@H:19]([NH:29][C:30](=[O:47])[CH2:31][N:32]2[C:36]3[C:37]([F:42])([F:41])[C@@H:38]4[CH2:40][C@@H:39]4[C:35]=3[C:34]([C:43]([F:46])([F:45])[F:44])=[N:33]2)[CH2:20][C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[CH:22]=2)=[N:4][CH:5]=[C:6]([N:8]2C(=O)C3C(=CC=CC=3)C2=O)[CH:7]=1>C(O)C.O.NN>[NH2:8][C:6]1[CH:7]=[C:2]([Br:1])[C:3]([C@@H:19]([NH:29][C:30](=[O:47])[CH2:31][N:32]2[C:36]3[C:37]([F:42])([F:41])[C@@H:38]4[CH2:40][C@@H:39]4[C:35]=3[C:34]([C:43]([F:44])([F:45])[F:46])=[N:33]2)[CH2:20][C:21]2[CH:22]=[C:23]([F:28])[CH:24]=[C:25]([F:27])[CH:26]=2)=[N:4][CH:5]=1

Participants

4

Reactant 1

HCID 90281393HCID 90281393, compound

Product 1

HCID 90281431HCID 90281431, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 24654Hydrazine hydrate (1:1)Solvent

Procedure

To a mixture of Compound 41B (100 mg, 0.14 mmol) in 15 ml of ethanol, 0.05 ml of hydrazine monohydrate was added and the reaction mixture was stirred at room temperature for 10 min. The solvent was removed and the residue was purified by RP-HPLC eluting with acetonitrile/H2O (with 0.1% TFA) to afford the title product. MS (m/z) 592.20 [M+H]+.

Workup

  1. additionwas added
  2. customThe solvent was removed
  3. customthe residue was purified by RP-HPLC
  4. washeluting with acetonitrile/H2O (with 0.1% TFA)

Sources & evidence

ORD record
ord-b5efbb459f2144c8ae479edd2836d4ec
Source dataset
uspto-grants-2015_06
Patent number
US09050344B2

Reaction notes

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