反应详情

Lithium hydroxide hydrate (0.40 g, 9.6 mmol) was added to a solution of methyl 4-(2-methoxypropan-2-yl)benzoate (0.10 g, 0.48 mmol) in tetrahydrofuran (9 mL), methanol (3 mL) and water (3 mL). The reaction mixture was stirred at room temperature for 2 hours. After the reaction, the solvent was removed in vacuo. Hydrochloric acid (3 mol/L) was added to make pH 2-3, and the product was extracted with dichloromethane (50 mL). The combined organic phase was washed with sodium chloride aqueous solution (50 mL×3), dried over anhydrous sodium sulfate, and the solvent was evaporated to dryness to give pure product 4-(2-methoxypropan-2-yl)benzoic acid (0.09 g, 96%) as a white solid.

1. customAfter the reaction
2. customthe solvent was removed in vacuo
3. additionHydrochloric acid (3 mol/L) was added
4. extractionthe product was extracted with dichloromethane (50 mL)
5. washThe combined organic phase was washed with sodium chloride aqueous solution (50 mL×3)
6. dry with materialdried over anhydrous sodium sulfate
7. customthe solvent was evaporated to dryness