Benzoyl chloride → HCID 71075681, compound

HRID 2170611Notes

Reaction equation

HRID 2170611 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]1([CH:16]([NH:19][C:20]([C:22]2[CH:23]=[C:24]3[C:28](=[CH:29][CH:30]=2)[NH:27][CH:26]=[CH:25]3)=[O:21])[CH2:17][CH3:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.CCN(CC)CC>C(Cl)Cl>[C:1]([N:27]1[C:28]2[C:24](=[CH:23][C:22]([C:20]([NH:19][CH:16]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH2:17][CH3:18])=[O:21])=[CH:30][CH:29]=2)[CH:25]=[CH:26]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 63717133HCID 63717133, compound

Product 1

HCID 71075681HCID 71075681, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Benzoyl chloride (1.1 equiv) was added to a solution of N-(1-phenylpropyl)-1H-indole-5-carboxamide in CH2Cl2, Et3N (1.3 equiv) at room temperature. After the reaction was completed, the solvent was evaporated and the residual was purified by silica gel column chromatography to get the product. LC-MS 383 (M+H).

Workup

  1. customthe solvent was evaporated
  2. customthe residual was purified by silica gel column chromatography
  3. customto get the product

Sources & evidence

ORD record
ord-d07632d5b0d8436f880b4abe05866b48
Source dataset
uspto-grants-2015_06
Patent number
US09051265B2

Reaction notes

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