Water → Indirubin-3'-monoxime

HRID 2170830노트

반응식

HRID 2170830 반응식
[CH:1]1[CH:2]=[CH:3][C:4]2[NH:9][C:8]([OH:10])=[C:7]([C:11]3[C:19](=O)[C:18]4[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=4[N:12]=3)[C:5]=2[CH:6]=1.[Cl-].[OH:22][NH3+:23].O>N1C=CC=CC=1>[CH:1]1[CH:2]=[CH:3][C:4]2[NH:9][C:8]([OH:10])=[C:7]([C:11]3[NH:12][C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=4[C:19]=3[N:23]=[O:22])[C:5]=2[CH:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 101772H-Indol-2-one, 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-HCID 21645Hydroxylamine HCl

생성물 1

HCID 3707Indirubin-3'-monoxime수율 90.2%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Indirubin (0.64 g, 2.4 mmol) was dissolved in anhydrous pyridine (25 mL), and hydroxylammonium chloride (1.67 g, 24 mmol) was added to the solution. The reaction liquid was heated and refluxed for 2.5 hours and then cooled to room temperature. The reaction liquid was poured into water (100 mL), and the precipitated crude crystals were collected by suction filtration. The resulting crude crystals were recrystallized from methanol/water to give red needle-shaped crystals of indirubin-3′-oxime (0.60 g, 89%).

후처리

  1. customThe reaction liquid
  2. temperaturewas heated
  3. temperaturerefluxed for 2.5 hours
  4. customThe reaction liquid
  5. customthe precipitated crude crystals
  6. filtrationwere collected by suction filtration
  7. customThe resulting crude crystals were recrystallized from methanol/water

출처 및 근거

ORD 기록
ord-39632d1f5b3d4e7081ce75a444af585b
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051306B2

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