2-Bromoethyl methyl ether → HCID 67168854, compound

HRID 2170843Notes

Reaction equation

HRID 2170843 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[O:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1.Br[CH2:23][CH2:24][O:25][CH3:26]>>[CH3:26][O:25][CH2:24][CH2:23][O:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[O:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:16])[CH3:17])=[O:13])[CH2:8][CH2:7]1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 60047515HCID 60047515, compound

Product 1

HCID 67168854HCID 67168854, compoundYield 96%

Procedure

The title compound was prepared in 96% yield (355 mg, colorless syrup) from tert-butyl 4-(3-hydroxyphenoxy)piperidine-1-carboxylate (300 mg, 1.02 mmol) and 1-bromo-2-methoxyethane (171 mg, 1.23 mmol) at a reaction temperature of 60° C. by the similar manner in Step-1 of Intermediate-2.

Sources & evidence

ORD record
ord-a68b76c95bb94293852bc8c6e67de64c
Source dataset
uspto-grants-2015_06
Patent number
US09051296B2

Reaction notes

Loading…