反应详情

温度

60 °C

A mixture of methyl 3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzoate (301 mg, 0.81 mmol, Step-1), 2M sodium hydroxide aqueous solution (2 mL), tetrahydrofuran (2 mL), and methanol (2 mL) was stirred at 60° C. for 2 hours. The mixture was acidified by 2M aqueous hydrochloric acid solution and extracted with ethyl acetate (10 mL). The organic layer was dried over sodium sulfate, and concentrated under reduced pressure to give 270 mg (93% yield) of the title compound as a white solid.

1. extractionextracted with ethyl acetate (10 mL)
2. dry with materialThe organic layer was dried over sodium sulfate
3. concentrationconcentrated under reduced pressure