HCID 86723573, compound → HCID 86723572, compound

HRID 2170919Notes

Reaction equation

HRID 2170919 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][N:7]([C:9]3[C:14]([F:15])=[CH:13][N:12]=[C:11]([C:16]([O-:18])=[O:17])[CH:10]=3)[CH:8]=2)[CH2:3][CH2:2]1>Cl>[CH:1]1([C:4]2[N:5]=[CH:6][N:7]([C:9]3[C:14]([F:15])=[CH:13][N:12]=[C:11]([C:16]([OH:18])=[O:17])[CH:10]=3)[CH:8]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 1

HCID 86723573HCID 86723573, compound

Product 1

HCID 86723572HCID 86723572, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

4-(4-cyclopropyl-1H-imidazol-1-yl)-5-fluoropicolinate (640 mg, 2.11 mmol) was dissolved in 1N HCl (5 mL) and the reaction was heated to 100° C. overnight. The solvent was removed, CH3CN was added and the solvent removed to afford 4-(4-cyclopropyl-1H-imidazol-1-yl)-5-fluoropicolinic acid which was used directly in subsequent reactions (assuming 100% conversion).

Workup

  1. customThe solvent was removed
  2. additionCH3CN was added
  3. customthe solvent removed

Sources & evidence

ORD record
ord-9eee23859f4d47e68d686b9edebb1d92
Source dataset
uspto-grants-2015_06
Patent number
US09051313B2

Reaction notes

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