反应详情

温度

75 °C

To a stirring solution of 5-(4-ethoxy-2-hydroxy-3-methoxyphenyl)isobenzofuran-1(3H)-one (30 mg, 0.1 mmol) in acetonitrile (5 mL) was added potassium carbonate (41 mg, 0.30 mmol) and ethyl iodide (62 mg, 0.40 mmol) and the resultant reaction mixture was heated to 75° C. for 2 h. The reaction mixture was cooled to RT, filtered through celite and the filtrate was concentrated under reduced pressure. Purification of the residue by flash column chromatography (silica gel, 0-20% ethyl acetate in pet ether) afforded the title compound as a solid (20 mg, 61%).

1. customthe resultant reaction mixture
2. temperatureThe reaction mixture was cooled to RT
3. filtrationfiltered through celite
4. concentrationthe filtrate was concentrated under reduced pressure
5. customPurification of the residue by flash column chromatography (silica gel, 0-20% ethyl acetate in pet ether)