Hydrochloric Acid → HCID 178526496, compound

HRID 2171217Notes

Reaction equation

HRID 2171217 reaction equation
O.[NH2:2][NH2:3].CCO.Cl[C:8]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:9]=1[C:10](OC)=[O:11].Cl>O>[N+:18]([C:15]1[CH:14]=[C:9]2[C:8](=[CH:17][CH:16]=1)[NH:3][N:2]=[C:10]2[OH:11])([O-:20])=[O:19]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 22754Methyl 2-chloro-5-nitrobenzoateHCID 24654Hydrazine hydrate (1:1)

Product 1

HCID 178526496HCID 178526496, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

Hydrazine monohydrate (19 ml) was added to an EtOH (15 ml) solution containing methyl 2-chloro-5-nitrobenzoate (10 g), followed by stirring at 90° C. for 1 hour. The reaction solution was adjusted to room temperature. Water and concentrated hydrochloric acid (32 ml) were added dropwise to the reaction solution. A solid precipitate was collected by filtration and washed with water. A brown solid of 5-nitro-1H-indazol-3-ol (5.42 g) was thus obtained.

Workup

  1. customwas adjusted to room temperature
  2. filtrationA solid precipitate was collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-b3c9faa27fe54aef90c69aacd712dd89
Source dataset
uspto-grants-2015_06
Patent number
US09051310B2

Reaction notes

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