Triethylamine → HCID 86728315, compound

HRID 2171330Notes

Reaction equation

HRID 2171330 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.C(N(CC)CC)C.[NH2:17][C:18]([CH3:22])([CH3:21])[CH2:19][OH:20]>C(#N)C>[Cl:1][C:2]1[N:3]=[C:4]([NH:17][C:18]([CH3:22])([CH3:21])[CH2:19][OH:20])[CH:5]=[C:6]([Cl:8])[N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 118072-Amino-2-methyl-1-propanolHCID 773782,4,6-Trichloropyrimidine

Product 1

HCID 86728315HCID 86728315, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 2,4,6-trichloropyrimidine (20.0 g, 109 mmol) in acetonitrile (500 mL) was added triethylamine (11.03 g, 109 mmol) at 0° C. After 5 min at room temperature, 2-amino-2-methylpropan-1-ol (9.72 g, 109 mmol) was added portionwise. The reaction mixture was stirred for another 1 h at room temperature, filtered and concentrated. Purification via silica gel column (ethyl acetate/petroleum ether=1/10 to 1/1) afforded the title product.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated
  3. customPurification via silica gel column (ethyl acetate/petroleum ether=1/10 to 1/1)

Sources & evidence

ORD record
ord-c67683f7c81e494b9f71898b96373640
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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