反应详情

温度

0 °C

To a solution of 2,4,6-trichloropyrimidine (5.42 mL, 47.1 mmol) and triethylamine (19.7 mL, 141 mmol) in acetonitrile (40 mL) was slowly added (S)-2-(methylamino)propan-1-ol (6.30 g, 70.7 mmol) in N,N-dimethylformamide (DMF) (3.00 mL) at 0° C. The reaction mixture was stirred at 0° C. for 1 h, filtered, dried over anhydrous Na2SO4, concentrated. Purification via flash chromatography column (petroleum ether/ethyl acetate=10/1) afforded the title product.

1. customat 0° C
2. filtrationfiltered
3. dry with materialdried over anhydrous Na2SO4
4. concentrationconcentrated
5. customPurification via flash chromatography column (petroleum ether/ethyl acetate=10/1)