Potassium Carbonate → HCID 135743575, compound

HRID 2171345Notes

Reaction equation

HRID 2171345 reaction equation
Br[CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9]([Cl:11])[N:8]=[C:7](Cl)[N:6]=1.C([O-])([O-])=[O:14].[K+].[K+]>O1CCOCC1.O>[Cl:11][C:9]1[CH:10]=[C:5]2[NH:4][CH2:3][CH2:2][N:6]2[C:7](=[O:14])[N:8]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 86724161HCID 86724161, compound

Product 1

HCID 135743575HCID 135743575, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
70 °C

Procedure

To a mixture of N-(2-bromoethyl)-2,6-dichloropyrimidin-4-amine (10 g, 18 mmol) in 1,4-dioxane (30 mL) and water (30.0 mL) was added K2CO3 (4.85 g, 35.1 mmol). The reaction mixture was stirred at 70° C. for 4 h, then directly used into next step without workup and purification.

Workup

  1. customdirectly used into next step without workup and purification

Sources & evidence

ORD record
ord-8562e7c7119a4ae18bd200313ce49d34
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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