Iodoethane → HCID 86728330, compound

HRID 2171357Notes

Reaction equation

HRID 2171357 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[NH:11][C:10]([CH3:13])([CH3:12])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.I[CH2:15][CH3:16].C([O-])([O-])=O.[Cs+].[Cs+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]2[N:11]([CH2:15][CH3:16])[C:10]([CH3:13])([CH3:12])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 10796Cesium carbonateHCID 136341368HCID 136341368, compound

Product 1

HCID 86728330HCID 86728330, compoundYield 96.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of 7-chloro-2,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (100 mg, 0.501 mmol) and iodoethane (94.0 mg, 0.601 mmol) in acetonitrile (4 mL) was added Cs2CO3 (326 mg, 1.00 mmol). The reaction mixture was stirred at 90° C. for 1 h, filtered and concentrated to afford the crude product (110 mg) as a brown solid.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-3927c75369294be5a4caf5c109063e64
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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