Iodoethane → HCID 86728331, compound

HRID 2171358Notes

Reaction equation

HRID 2171358 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[NH:11][C@@H:10]([CH3:12])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.I[CH2:14][CH3:15].C([O-])([O-])=O.[Cs+].[Cs+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]2[N:11]([CH2:14][CH3:15])[C@@H:10]([CH3:12])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 10796Cesium carbonateHCID 136341369HCID 136341369, compound

Product 1

HCID 86728331HCID 86728331, compoundYield 139.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of (S)-7-chloro-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (50.0 mg, 0.269 mmol) and iodoethane (63.0 mg, 0.404 mmol) in acetonitrile (1 ml) was added Cs2CO3 (176 mg, 0.539 mmol). The reaction mixture was stirred at 90° C. for 1 h, filtered and concentrated to give crude product (80 mg) as a brown solid.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-410ac82c34264e92b66586a0b47f7c37
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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