Potassium Carbonate → HCID 86728339, compound

HRID 2171367Notes

Reaction equation

HRID 2171367 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11](S(C)(=O)=O)[C:10]([CH3:17])([CH3:16])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[OH:18][CH2:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[C:23]#[N:24].C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[CH3:16][C:10]1([CH3:17])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=[C:2]([O:18][CH2:19][C:20]3[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=3)[C:23]#[N:24])[CH:3]=[C:4]2[NH:11]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27346773-(Hydroxymethyl)benzonitrileHCID 86728340HCID 86728340, compound

Product 1

HCID 86728339HCID 86728339, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 7-chloro-2,2-dimethyl-1-(methylsulfonyl)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (200 mg, 0.720 mmol) and 3-(hydroxymethyl)benzonitrile (288 mg, 2.16 mmol) in N,N-dimethylformamide (DMF) (3.5 mL) was added K2CO3 (299 mg, 2.16 mmol). The reaction mixture was sealed in a microwave vial and irradiated with a microwave using initial normal to 100° C. for 1 h. Purification via mass-directed auto-preparation afforded the title product as a white solid.

Workup

  1. customThe reaction mixture was sealed in a microwave vial
  2. customirradiated with a microwave
  3. customnormal to 100° C.
  4. customfor 1 h
  5. customPurification
  6. customvia mass-directed auto-preparation

Sources & evidence

ORD record
ord-6afb1580249e4240a4cc3004996aba0a
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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