Potassium Carbonate → HCID 86728388, compound

HRID 2171408Notes

Reaction equation

HRID 2171408 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11](S(C)(=O)=O)[C:10]([CH3:17])([CH3:16])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[F:18][C:19]1[CH:20]=[C:21]([CH2:27][OH:28])[CH:22]=[C:23]([F:26])[C:24]=1[F:25].C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[CH3:16][C:10]1([CH3:17])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=[C:2]([O:28][CH2:27][C:21]3[CH:22]=[C:23]([F:26])[C:24]([F:25])=[C:19]([F:18])[CH:20]=3)[CH:3]=[C:4]2[NH:11]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27770403,4,5-Trifluorobenzyl alcoholHCID 86728340HCID 86728340, compound

Product 1

HCID 86728388HCID 86728388, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 7-chloro-2,2-dimethyl-1-(methylsulfonyl)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (180 mg, 0.648 mmol) and (3,4,5-trifluorophenyl)methanol (210 mg, 1.30 mmol) in N,N-dimethylformamide (DMF) (3.5 mL) was added K2CO3 (269 mg, 1.94 mmol). The reaction mixture was sealed in a microwave vial and irradiated with a microwave using initial normal to 100° C. for 1 h. Purification via MDAP afforded the title product as a white solid.

Workup

  1. customThe reaction mixture was sealed in a microwave vial
  2. customirradiated with a microwave
  3. customnormal to 100° C.
  4. customfor 1 h
  5. customPurification via MDAP

Sources & evidence

ORD record
ord-7347299418d14c399660d285e6736ce3
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

Loading…