反应详情

67.5 g (248 mmol) of 4-amino-6-(2,4-dichlorophenyl)pyrimidine-2(1H)-thione and 77.37 g (496.04 mmol) of iodoethane are dissolved in 560 ml of dry DMSO and, at RT, 270 ml of a saturated aqueous sodium bicarbonate solution are slowly added. The mixture is stirred at RT for 5 h and then 440 ml of water are added. The precipitate is filtered off with suction, washed with water and sucked dry. It is stirred twice with 100 ml of isopropanol each time and again filtered off with suction. It is washed once more with petroleum ether and the residue is dried under high vacuum. 50.0 g (67% of theory) of the product are obtained as a solid.

1. filtrationThe precipitate is filtered off with suction
2. washwashed with water
3. customsucked dry
4. stirringIt is stirred twice with 100 ml of isopropanol each time
5. filtrationagain filtered off with suction
6. washIt is washed once more with petroleum ether
7. customthe residue is dried under high vacuum
8. custom50.0 g (67% of theory) of the product are obtained as a solid