反应详情

温度

120 °C

3.0 g (10.05 mmol) of 5-chloro-7-(2,4-dichlorophenyl)imidazo[1,2-c]pyrimidine, 2.41 g (15.07 mmol) of N-Boc-ethylenediamine and 3.89 g (30.15 mmol) of diisopropylethylamine are dissolved in 50 ml of DMSO and heated at 120° C. for 16 h. Ethyl acetate and water are added, and the removed organic phase is washed twice more with water. The organic phase is dried with magnesium sulphate. Removal of the solvent results in 4.49 g (99% of theory) of product.

1. washthe removed organic phase is washed twice more with water
2. dry with materialThe organic phase is dried with magnesium sulphate
3. customRemoval of the solvent
4. customresults in 4.49 g (99% of theory) of product