Potassium Bicarbonate → HCID 59312926, compound

HRID 2171493Notes

Reaction equation

HRID 2171493 reaction equation
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH2:12][CH:13]([CH3:23])[CH2:14][NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19].C(=O)(O)[O-].[K+]>>[NH2:1][C:2]1[N:3]=[C:4]([NH:12][CH:13]([CH3:23])[CH2:14][NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Participants

4

Reactant 3

HCID 516893Potassium BicarbonateHCID 27240356-Chloro-3-nitropyridin-2-ylamineHCID 22499135tert-Butyl (2-aminopropyl)carbamate

Product 1

HCID 59312926HCID 59312926, compound

Procedure

tert-Butyl {2-[(6-amino-5-nitropyridin-2-yl)amino]propyl}carbamate (Example 39A) is prepared in analogy to Example 38A from 2-amino-6-chloro-3-nitropyridine (637 mg, 3.7 mmol), tert-butyl (2-aminopropyl)carbamate (320 mg, 1.8 mmol) and potassium bicarbonate (368 mg, 3.7 mmol). 561 mg (98% of theory) of the product are obtained as a solid.

Workup

  1. custom561 mg (98% of theory) of the product are obtained as a solid

Sources & evidence

ORD record
ord-5a42eff6c70b43818670f1ecabbb59ef
Source dataset
uspto-grants-2015_06
Patent number
US09051323B2

Reaction notes

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