反应详情

tert-Butyl 3-(pyridin-4-yloxy)azetidine-1-carboxylate (494 mg) was mixed with DCE (5 ml), and TFA (2 ml) was added thereto, followed by stirring at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by basic silica gel column chromatography (CHCl3/MeOH) to obtain 4-(azetidin-3-yloxy)pyridine (268 mg).

1. additionwas added
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customthe obtained residue was purified by basic silica gel column chromatography (CHCl3/MeOH)